
Clarissa Viana Demézio da Silva
Federal University of Rio de Janeiro, BrazilTitle: Association Between Dietary Inflammatory Index, Endometriosis and Dyspareunia
Abstract
Recently, diet has been identified a potential
modifiable risk factor for endometriosis. Thus, the
aim of this study was to investigate the association
between the dietary inflammatory index (DII),
endometriosis, and its main symptoms. Woman
with endometriotic lesions by surgery or magnetic
resonance were defined as cases (n=59). Controls
(n=59) had no visible ectopic endometrium sites
during surgical. The present study focused on main
symptoms of endometriosis, such as
dysmenorrhea, chronic pelvic pain, deep
dyspareunia and infertility. Body mass index
(BMI=weight(kg)/height(m)2
) was calculated from
measured height and weight and waist
circumference was measured. A validated semi
quantitative food frequency questionnaire was used
to calculate the DII score. Women with
endometriosis were younger, thinner; and had a
more pro-inflammatory diet and more pain
(dysmenorrhea, chronic pelvic pain, deep
dyspareunia), than controls. Women with higher
DII scores (>0.86) were more likely to have
endometriosis and to present with dyspareunia.
Results obtained from modeling DII as a
categorical variable in relation to risk of
endometriosis showed a near tripling of risk (OR =
2.77; 95% CI = 1.13–6.77) for women with DII
>0.86 versus those with DII ? 0.86, after adjusting
for age and BMI. After multivariable adjustment,
women with DII > 0.86 were four times more likely
to have endometriosis compared to women with
DII ? 0.86(OR = 4.14; 95% CI= 1.50–11.4). In
conclusion, a pro- inflammatory diet was
significantly associated with endometriosis and
dyspareunia in a case-control study in Brazil.
Biography
Clarissa Viana Demézio da Silva
has completed her PHD in 2021 at Federal
University of Rio de Janeiro, Brazil. She is the head
of research about endometriosis and nutrition in
Brazil. Author of the first study that demonstrated
the association between inflammatory diet and
endometriosis.