Virtual Conference
Nutrition 2022

Ivan Kenneth S. Zapanta

Makati Medical Center, Philippines

Title: Efficacy of Skimmed Milk Administration in Mild and Moderate Hypophosphatemia (SMPhos): An Open-Label Randomized Controlled Clinical Trial


Currently, there are no formal guidelines for correcting hypophosphatemia and an unavailability of oral phosphate supplements. A non-inferiority, open-label, randomized controlled pilot trial was done to compare skimmed milk with phosphate solutions in raising serum phosphorus levels in patients with mild and moderate hypophosphatemia. A total of 41 participants were randomized. Treatment difference was determined using the mean percent change, with the non-inferiority limit at 15%. Adverse events were noted, and intention to treat was done. Skimmed milk raised phosphorus but was not different from phosphate solution (2.62 vs 3.02 mg/dL). The mean percent change was higher in the phosphate solution (50.32% vs 30.93%) but was not significant. The mean percent change difference is -19.39. There was abdominal pain and vomiting with phosphate solution. Skimmed milk was able to raise serum phosphorus levels in mild or moderate hypophosphatemia however, non-inferiority was not met. Skimmed milk is still a safe, available, and inexpensive alternative in resource-limited areas.


Ivan Zapanta is an Internal Medicine resident at Makati Medical Center, Philippines. He earned his medical degree at University of Santo Tomas, Manila and completed his undergraduate degree in Community Nutrition at University of the Philippines – Diliman. Aside from being a doctor, he is also a registered nutritionist-dietitian.