Virtual Conference
Nutrition 2022

Shaw Watanabe

Tokyo University of Agriculture , Japan

Title: Dietary therapy with low protein genmai (brown rice) to improve the gut-kidney axis and reduce CKD progression


Low protein rice can be part of a nutritionally  adequate dietary pattern  in the prevention of chronic kidney disease. We developed   a  low protein[MW1]  genmai (brown rice) (FLPG[MW2] ) to improve  chronic kidney disease (CKD management. The principal functional features  of brown rice are retained in LPG, lessening  the negative spiral of gut-kidney associative spiral  attributable  to uremic dysbiosis and a leaky gut. LPG is characterized by (1) an energy value the same as  white rice, (2) a protein content less than 0.2 g/ 100g , (3) a potassium content  almost zero, (4) phosphorus less than a quarter that of conventional rice , (5) the presence of dietary fiber, (6)?having g-oryzanol, and (7) antioxidant[MW3]  activity.
Dietary therapy for CKD patients is challenged by the joint needs  to provide enough energy and to restrict protein .  Patients replaced  staple foods with FLPG without  side dish restriction .  Preliminary study of intervention with  3 months of FLPG reduced  constipation probably by  increased Blautia wexlerae, Bifidobacteria, acetic acid, and a decrease in potentially  harmful bacteria. Protein intake decreased from 60  to 50 g per  day. Urinary protein excretion decreased from 510 to 300 mg per day, and b2-microglobulin   from 926 to 250?g/L. Adherence to the FLPG diet enabled improvement in  glomerular and tubular function.   


Shaw Watanabe is a Pathologist, Epidemiologist, Nutritionist, Public Health Scientist in Japan. He graduated from Keio University, Medical School and he Studied at NCI, USA. He is a Professor in Tokyo University of Agriculture. He is a President in National Institute of Health and Nutrition, Japan Society for the Promotion of Life Sciences, Asia-Pacific Society of Clinical Nutrition and Medical Rice Association. He got an award of WHO Memorial Medal, Japan Medical Association Medical Award, Sanshikai Social Merit Award and Asia Pacific Clinical Nutrition Society Award. He published more than 800 papers in the field of pathology, epidemiology, clinical nutrition, agriculture and public health.