Shaw WatanabeTokyo University of Agriculture , Japan
Title: Dietary therapy with low protein genmai (brown rice) to improve the gut-kidney axis and reduce CKD progression
Low protein rice can be part of a nutritionally adequate dietary pattern in the prevention of chronic kidney disease. We developed a low protein[MW1] genmai (brown rice) (FLPG[MW2] ) to improve chronic kidney disease (CKD management. The principal functional features of brown rice are retained in LPG, lessening the negative spiral of gut-kidney associative spiral attributable to uremic dysbiosis and a leaky gut. LPG is characterized by (1) an energy value the same as white rice, (2) a protein content less than 0.2 g/ 100g , (3) a potassium content almost zero, (4) phosphorus less than a quarter that of conventional rice , (5) the presence of dietary fiber, (6)?having g-oryzanol, and (7) antioxidant[MW3] activity.
Dietary therapy for CKD patients is challenged by the joint needs to provide enough energy and to restrict protein . Patients replaced staple foods with FLPG without side dish restriction . Preliminary study of intervention with 3 months of FLPG reduced constipation probably by increased Blautia wexlerae, Bifidobacteria, acetic acid, and a decrease in potentially harmful bacteria. Protein intake decreased from 60 to 50 g per day. Urinary protein excretion decreased from 510 to 300 mg per day, and b2-microglobulin from 926 to 250?g/L. Adherence to the FLPG diet enabled improvement in glomerular and tubular function.
Shaw Watanabe is a Pathologist, Epidemiologist, Nutritionist, Public Health Scientist in Japan. He graduated from Keio University, Medical School and he Studied at NCI, USA. He is a Professor in Tokyo University of Agriculture. He is a President in National Institute of Health and Nutrition, Japan Society for the Promotion of Life Sciences, Asia-Pacific Society of Clinical Nutrition and Medical Rice Association. He got an award of WHO Memorial Medal, Japan Medical Association Medical Award, Sanshikai Social Merit Award and Asia Pacific Clinical Nutrition Society Award. He published more than 800 papers in the field of pathology, epidemiology, clinical nutrition, agriculture and public health.