Virtual Conference
Nutrition 2022

Hayri Gözlükgiller

Altinbas University, Istanbul, Turkey

Title: The Protective Effect of Omega 3 and Vitamin D in Preventing Damage Occurring in Central Nervous System of Neonatal Rats Exposed to Cigarette Smoke in Intrauterine Period

Abstract

Purpose: In our study, the toxic effects of cigarette smoke exposure on central nervous system and the protective role of Omega 3 and Vitamin D against these toxic effects were investigated at biochemical and histological level. 
Methods and tools: 28 adult female pregnant Wistar-Albino rats were separated into four groups. The first group of rats was our control group. The second group of rats was the group of rats, we have exposed to smoke of 10 cigarettes via puff device 2 hours/day following conception. The third group was the group, to which we have administered Omega 3 (0.5 mg/kg/day) with cigarette smoke, and the fourth group was the group, to which we have administered Vitamin D (42 microgram/kg/day) with cigarette smoke. At the end of the experiment, the sections, collected from brain tissue and medulla spinalis were stained by hematoxylin eosin and .........dye. The levels of Malondialdehyde (MDA) and Fluorescent Oxidation Products (FOU) were the measured biochemical parameters. 
Results: We have found the fetal weight and the number of fetuses significantly low only in the group, exposed to cigarette smoke. In the histopathological examination of the brain and spinal cord tissue, we observed that the histopathological changes of the fetuses, exposed to cigarette smoke, were significantly reduced in the group, to which ……Omega 3 and Vitamin D was administered. We have detected that MDA and FOU levels increased with statistical significance in the group, exposed to cigarette smoke, compared to control group (p<0.001), and that MDA and FOU levels were lower in the group, exposed to cigarette smoke along with Omega 3 administration (p<0.001). 

Biography

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