Pranita Jwalant Waghmare
Mahatma Gandhi Institute of Medical Sciences, IndiaTitle: High levels of serum ferritin and poor COVID 19 outcome: Nutritional prospect, a lost viewpoint
Abstract
COVID 19 disease related pathogenesis is still under investigation. Preliminary reports suggest a link between ABO blood group, serum ferritn levels as a determinants of susceptibility to severe COVID‐19 disease. With this aim this study was to carried out to strengthen the link between high ferritn levels and coronavirus infection. This was a retrospective cohort study carried out at tertiary care rural hospital in Central India. The all patients admitted to the COVID unit over 6 months during June-December 2021 were enrolled in the study. The retrived data further statistically analyzed for the outcome of COVID‐19 disease and its relation with the patient’s blood group and serum ferritin levels. The high mortality rate was 27.2% in the AB blood group, with the highest reported serum ferritin levels (1007.78 ± 1301.25)µg/L . Compared to other blood groups B (8.1%), was with the lowest mortality rate with serum ferritn (500.48±562.58) µg/L. Data analysis revealed, there was no statistical significant impact of blood group on the outcome of COVID‐19. However, it was perspicuous that high levels of serum ferritn are related to raised mortality in COVID 19. We concluded that high serum ferritin levels can predict COVID 19 mortality and may be considered the culprit for the triggering “cytokine storm.”With milieu of serum ferritin levels, we also recommend to study the levels of trasferritin levels reflecting the long nutritional status of patient may be also be responsible for the high levels of iron triggering inflammation in COVID infection and consequently the ‘cytokine storm’ .
Biography
Pranita Jwalant Waghmare has completed her MD in Biochemistry from Maharashtra University of Health Sciences, Nashik, India. Currently, she is an Associate Professor, at the Department of Biochemistry, MGIMS, Sevagram, India. She has credit for more than 50 publications, cited over 350 times, and h-index 10. She has been working on a funded research project by the Government of India as PI & COPI.
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