Saber JedidiSylvo-Pastoral Institute of Tabarka, Tunisia
Title: Valorization of bioactive substances with pharmacological activities isolated from plants of the Lamiacea family
The aim of this study was to investigate the chemical composition, the antioxidant and antibacterial capacities of Rosmarinus officinalis essential oils (ROEO) and Salvia officinalis extract (SOE) as well as their protective effects against gastrointestinal diseases. Essential oils and extract samples were analyzed by GC–MS and LC-MS, respectively. In vivo, gastro-intestinal (GI)/physiological/pharmacological actions of ROEO/SOE were explored based on the watery/frequent stools, enteropooling, GI transit time, peptic ulcer and ulcerative colitis. Our result firstly indicated that the antioxidant capacity by 2,2-diphenyl-1-picrylhydrazyl (DPPH?) test showed that ROEO and SOE had an important antioxidant capacities. More importantly, ROEO/SOE significantly reduced castor oil (CO), ethanol (EtOH) and acetic acid (AA)-induced diarrhea, peptic ulcer and ulcerative colitis in a dose-dependent manner. ROEO/SOE decreased also the gastro-intestinal and colonic mucosal malondialdehyde/hydrogen peroxide levels and preserved the normal activities/levels of enzymatic/non enzymatic antioxidants. These findings suggested that ROEO/SOE exerted benefic effects confirming their use as a strategy in the treatment of GI physiological disorders.
Doctor in Biological Sciences, Specialty: Animal Physiology. Head of laboratory and researcher in the field: Valorization of bioactive molecules and their preventive actions on digestive pathologies and associated metabolic disorders induced experimentally. H-index is 8. He has been serving as an reviewer of several reputed journals.